Regulation of BMP signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of BMP signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF320, ZNF28, and EIF3CL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF320 grouped by Regulation of BMP signaling pathway-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZNF320 →	-1.723	-0.200	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	ZNF28 →	-1.801	-0.187	.004	.004	3	4
CNS	EIF3CL →	-0.757	-0.222	.001	.005	3	4
LUNG_NSCLC_LUAD	MVK →	-0.894	-0.163	.001	<.001	3	3
SOFT_TISSUE	ACLY →	-0.891	-0.198	.001	.003	3	3
SOFT_TISSUE	PPFIA4 →	-2.018	-0.144	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF320 by Regulation of BMP signaling pathway activity — SKIN

Explore this box plot interactively →