Regulation of BMP signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of BMP signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAV2, CDC42EP3, and CPT2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of BMP signaling pathway activity versus CAV2 in LARGE_INTESTINE (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CAV2 →	+2.210	+0.319	.005	.005	3	8
STOMACH	CDC42EP3 →	+2.779	+0.640	<.001	.005	3	6
SOFT_TISSUE	CPT2 →	-1.341	-0.338	.002	.001	3	6
SOFT_TISSUE	POLR3K →	-0.720	-0.154	.002	.001	2	7
SOFT_TISSUE	ELFN2 →	+2.283	+0.298	<.001	<.001	3	6
SOFT_TISSUE	IL31RA →	+2.001	+0.262	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030510 vs CAV2 — LARGE_INTESTINE

Explore this scatter interactively →