Negative regulation of bone mineralization

Across TCGA cell cohorts, RNA activity of the Negative regulation of bone mineralization pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKAR1B, PSME4, and SRI, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRKAR1B grouped by Negative regulation of bone mineralization-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PRKAR1B →	-1.250	-1.125	.005	.006	3	4
URINARY_TRACT	PSME4 →	+1.117	+1.999	.005	<.001	3	3
URINARY_TRACT	SRI →	+1.210	+1.767	.001	<.001	3	3
CNS	FAM90A1 →	+0.157	+0.806	.004	<.001	3	3
OESOPHAGUS	DENND1A →	-0.800	-1.044	.003	<.001	3	3
LARGE_INTESTINE	AFMID →	+0.725	+0.956	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRKAR1B by Negative regulation of bone mineralization activity — OESOPHAGUS

Explore this box plot interactively →