Positive regulation of bone mineralization

Across TCGA patient cohorts, RNA activity of the Positive regulation of bone mineralization pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EMILIN1, LMO2, and RABIF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of bone mineralization activity versus EMILIN1 in LUAD (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EMILIN1 →	+0.580	+0.627	.002	.004	3	4
BRCA	LMO2 →	+0.500	+0.782	.008	<.001	3	4
PDAC	RABIF →	-0.392	-0.719	<.001	.001	3	4
COAD	FAM89A →	+0.326	+0.320	.009	.003	3	3
COAD	ST13P15 →	+0.310	+0.442	<.001	.005	3	3
LSCC	SH3BP1 →	+0.354	+0.748	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030501 vs EMILIN1 — LUAD

Explore this scatter interactively →