Positive regulation of bone mineralization

Across TCGA cell cohorts, RNA activity of the Positive regulation of bone mineralization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCT7, MON1B, and PHIP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCT7 grouped by Positive regulation of bone mineralization-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CCT7 →	+0.488	+0.744	.006	.002	3	5
KIDNEY	MON1B →	+1.242	+1.095	.002	.001	3	4
SOFT_TISSUE	PHIP →	-0.976	-1.418	.006	.001	3	4
PANCREAS	RRAGD →	+1.904	+0.778	<.001	.008	3	4
SOFT_TISSUE	ASCC3 →	-0.877	-0.998	.005	.009	3	3
SOFT_TISSUE	UBR5 →	-0.981	-1.204	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCT7 by Positive regulation of bone mineralization activity — BREAST

Explore this box plot interactively →