Positive regulation of bone mineralization

Across TCGA cell cohorts, RNA activity of the Positive regulation of bone mineralization pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LBHD1, ECE1, and FLNC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of bone mineralization activity versus LBHD1 in STOMACH (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LBHD1 →	+0.985	+1.253	.004	.006	3	4
BREAST	ECE1 →	+1.221	+0.944	.001	.003	3	4
OVARY	FLNC →	+2.550	+0.803	.008	.005	3	4
BONE	CSTF1 →	-0.675	-1.665	.003	.002	3	4
URINARY_TRACT	SLC39A8 →	+1.745	+1.440	<.001	<.001	3	3
URINARY_TRACT	TMEM19 →	-1.382	-1.797	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030501 vs LBHD1 — STOMACH

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