Positive regulation of bone mineralization

Across TCGA cell cohorts, RNA activity of the Positive regulation of bone mineralization pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ISG15, ATP2B1, and TALDO1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of bone mineralization activity versus ISG15 in LUNG_SCLC (Pearson r = 0.73).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ISG15 →	+2.566	+1.727	<.001	<.001	3	13
CNS	ATP2B1 →	+0.965	+0.808	<.001	.001	3	7
LUNG_NSCLC_LUAD	TALDO1 →	-1.378	-0.958	.002	.001	3	6
OVARY	ACTR3 →	-0.552	-0.586	.009	.006	3	6
BLOOD_Lymphoma	SP100 →	+1.470	+0.933	.001	.002	3	5
SOFT_TISSUE	RPS25 →	-0.425	-1.309	.007	.007	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030501 vs ISG15 — LUNG_SCLC

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