Regulation of bone mineralization

Across TCGA patient cohorts, RNA activity of the Regulation of bone mineralization pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNMB1, SIRPB2, and GBGT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of bone mineralization activity versus KCNMB1 in UCEC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KCNMB1 →	+0.887	+0.820	<.001	<.001	3	6
BRCA	SIRPB2 →	+0.488	+0.541	.001	.003	3	6
UCEC	GBGT1 →	+0.556	+0.714	<.001	.002	3	6
BRCA	IFFO1 →	+0.797	+0.753	<.001	<.001	3	5
BRCA	FAM20A →	+0.682	+0.543	.004	.008	2	6
BRCA	FN1 →	+1.259	+0.509	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030500 vs KCNMB1 — UCEC

Explore this scatter interactively →