Regulation of bone mineralization

Across TCGA cell cohorts, RNA activity of the Regulation of bone mineralization pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERTAD1, INTS2, and B3GALT4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SERTAD1 grouped by Regulation of bone mineralization-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SERTAD1 →	-0.651	-0.884	.003	<.001	3	4
PANCREAS	INTS2 →	+0.489	+1.125	.008	.005	3	4
PANCREAS	B3GALT4 →	-1.146	-1.100	.008	.001	3	4
OVARY	PLXNA3 →	-1.268	-1.066	.009	.009	3	4
LUNG_NSCLC_LUAD	RRP1B →	+0.424	+0.530	.006	.003	3	4
LIVER	CCDC146 →	-1.023	-1.103	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SERTAD1 by Regulation of bone mineralization activity — SKIN

Explore this box plot interactively →