Fatty acid elongation

Across TCGA patient cohorts, RNA activity of the Fatty acid elongation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KPNA2, CD248, and DNAJA3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid elongation activity versus KPNA2 in OV (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	KPNA2 →	+0.615	+0.054	.002	.002	3	6
GBM	CD248 →	-0.508	-0.070	<.001	<.001	3	6
LSCC	DNAJA3 →	+0.265	+0.042	<.001	.006	3	6
CCRCC	DOCK1 →	-0.140	-0.057	<.001	<.001	3	6
LUAD	CLCC1_S509 →	+0.436	+0.059	<.001	<.001	3	6
UCEC	GFM1 →	+0.409	+0.065	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030497 vs KPNA2 — OV

Explore this scatter interactively →