Maturation of SSU-rRNA

Across TCGA patient cohorts, RNA activity of the Maturation of SSU-rRNA pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are POLR1E, ADNP, and XPO5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maturation of SSU-rRNA activity versus POLR1E in BRCA (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	POLR1E →	+0.476	+0.022	<.001	.005	3	6
LSCC	ADNP →	+0.387	+0.056	<.001	<.001	3	6
LSCC	XPO5 →	+0.476	+0.037	<.001	<.001	3	6
LSCC	RRP15 →	+0.314	+0.039	<.001	<.001	3	6
LSCC	TMF1 →	-0.210	-0.042	<.001	<.001	3	6
LSCC	UTP4 →	+0.288	+0.038	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030490 vs POLR1E — BRCA

Explore this scatter interactively →