Maturation of SSU-rRNA

Across TCGA patient cohorts, RNA activity of the Maturation of SSU-rRNA pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMAHP, DDIAS, and C1QTNF7, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maturation of SSU-rRNA activity versus CMAHP in BRCA (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CMAHP →	-0.719	-0.303	.002	<.001	3	10
UCEC	DDIAS →	+0.737	+0.261	<.001	<.001	3	8
PDAC	C1QTNF7 →	-0.650	-0.187	<.001	.007	3	8
CCRCC	RCAN2 →	-1.387	-0.239	<.001	.008	2	9
BRCA	ABCA8 →	-1.086	-0.379	<.001	<.001	3	8
BRCA	LMOD1 →	-1.117	-0.404	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030490 vs CMAHP — BRCA

Explore this scatter interactively →