Maturation of SSU-rRNA

Across TCGA cell cohorts, RNA activity of the Maturation of SSU-rRNA pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOP58, PNO1, and CCDC86, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maturation of SSU-rRNA activity versus NOP58 in OESOPHAGUS (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NOP58 →	+1.006	+0.116	.001	.006	3	20
BLOOD_Lymphoma	PNO1 →	+0.915	+0.124	<.001	<.001	3	20
BLOOD_Lymphoma	CCDC86 →	+1.459	+0.132	<.001	<.001	3	20
PANCREAS	NOLC1 →	+1.286	+0.112	<.001	<.001	3	20
BONE	PA2G4 →	+1.265	+0.168	<.001	<.001	3	19
BONE	NOC4L →	+1.000	+0.143	.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030490 vs NOP58 — OESOPHAGUS

Explore this scatter interactively →