Maturation of SSU-rRNA

Across TCGA cell cohorts, RNA activity of the Maturation of SSU-rRNA pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTF2IRD2, RAB4B, and RNF19A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maturation of SSU-rRNA activity versus GTF2IRD2 in SKIN (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GTF2IRD2 →	-1.466	-0.447	<.001	<.001	3	7
BREAST	RAB4B →	-0.795	-0.308	.004	.008	3	7
BREAST	RNF19A →	-1.381	-0.323	.001	.002	3	7
CNS	FAM114A1 →	-1.057	-0.292	.004	.006	3	7
LARGE_INTESTINE	NAGK →	-0.816	-0.383	.004	.001	3	7
PANCREAS	POF1B →	-1.513	-0.382	.006	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030490 vs GTF2IRD2 — SKIN

Explore this scatter interactively →