tRNA methylation

Across TCGA patient cohorts, RNA activity of the tRNA methylation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TP53BP1, PTPN6_S10, and RBM12B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA methylation activity versus TP53BP1 in BRCA (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TP53BP1 →	+0.320	+0.025	<.001	<.001	3	6
LUAD	PTPN6_S10 →	-1.292	-0.033	<.001	<.001	3	6
GBM	RBM12B →	+0.296	+0.046	<.001	<.001	3	6
BRCA	EPM2AIP1 →	+0.480	+0.028	<.001	<.001	3	6
LSCC	SEC24A →	-0.338	-0.040	.005	<.001	3	6
UCEC	SLC16A3_S436 →	-0.715	-0.075	.005	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030488 vs TP53BP1 — BRCA

Explore this scatter interactively →