tRNA methylation

Across TCGA patient cohorts, RNA activity of the tRNA methylation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEGR1, TGIF1P1, and YIF1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA methylation activity versus NEGR1 in GBM (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NEGR1 →	-0.713	-0.133	<.001	<.001	3	5
GBM	TGIF1P1 →	-0.654	-0.180	.001	<.001	3	4
LSCC	YIF1B →	+0.259	+0.140	.005	.008	3	4
UCEC	ORC1 →	+0.762	+0.166	<.001	<.001	3	4
LSCC	KLC3 →	+0.916	+0.194	<.001	.001	3	4
UCEC	DHX34 →	+0.418	+0.159	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030488 vs NEGR1 — GBM

Explore this scatter interactively →