tRNA methylation

Across TCGA cell cohorts, RNA activity of the tRNA methylation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL37, ADAM9, and PIGO, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA methylation activity versus MRPL37 in PANCREAS (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MRPL37 →	+0.690	+0.239	.001	.003	3	4
LUNG_SCLC	ADAM9 →	-1.072	-0.168	.008	.003	3	4
OVARY	PIGO →	-0.889	-0.221	<.001	.001	3	4
LARGE_INTESTINE	BRIX1 →	+0.784	+0.181	<.001	.001	3	4
LUNG_NSCLC_LUAD	NDUFS6 →	+0.834	+0.172	.003	<.001	3	4
BLOOD_Lymphoma	CCL5 →	-2.931	-0.108	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030488 vs MRPL37 — PANCREAS

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