Regulation of complement activation

Across TCGA cell cohorts, RNA activity of the Regulation of complement activation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLIT2, PSTPIP2, and PURB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLIT2 grouped by Regulation of complement activation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SLIT2 →	-0.834	-0.305	.004	.004	3	4
CNS	PSTPIP2 →	-1.145	-0.610	.003	.007	3	3
LIVER	PURB →	-0.898	-0.242	.002	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	PLEKHG3 →	-1.161	-0.238	.001	.006	3	3
UPPER_AERODIGESTIVE_TRACT	TCAF2 →	-0.663	-0.212	.001	.007	3	3
UPPER_AERODIGESTIVE_TRACT	KIF24 →	-1.080	-0.301	.003	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLIT2 by Regulation of complement activation activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →