Regulation of complement activation

Across TCGA cell cohorts, RNA activity of the Regulation of complement activation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H3-3B, CD59, and WDR7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of complement activation activity versus H3-3B in BLOOD_Lymphoma (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	H3-3B →	+1.109	+0.220	.005	.005	3	5
STOMACH	CD59 →	+2.143	+0.249	.001	.001	2	5
LARGE_INTESTINE	WDR7 →	+0.670	+0.153	.008	.009	3	4
SOFT_TISSUE	EIF3M →	+0.638	+0.237	.005	.008	2	5
LUNG_SCLC	VCP →	-0.472	-0.239	.007	.002	3	4
LUNG_NSCLC_LUSC	LEPROTL1 →	+1.469	+0.232	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030449 vs H3-3B — BLOOD_Lymphoma

Explore this scatter interactively →