Sleep

Across TCGA cell cohorts, RNA activity of the Sleep pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADORA2A, RAB11FIP5, and CASD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADORA2A grouped by Sleep-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ADORA2A →	-0.307	-1.040	<.001	<.001	3	7
BREAST	RAB11FIP5 →	-0.269	-0.746	<.001	.005	3	6
LUNG_SCLC	CASD1 →	-0.306	-1.017	.001	.004	1	7
LUNG_SCLC	PER3 →	-0.443	-1.101	.002	.007	3	5
LUNG_NSCLC_LUSC	MTNR1B →	-0.270	-1.496	.004	.003	3	5
SOFT_TISSUE	PTGDS →	-0.357	-1.052	.007	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADORA2A by Sleep activity — SOFT_TISSUE

Explore this box plot interactively →