siRNA processing

Across TCGA patient cohorts, RNA activity of the siRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DICER1, RBM25, and AGO2, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, siRNA processing activity versus DICER1 in UVM (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	DICER1 →	+1.301	+0.079	<.001	<.001	3	31
UVM	RBM25 →	+1.477	+0.076	<.001	<.001	3	31
SCLC	AGO2 →	+1.764	+0.098	<.001	.001	1	33
UVM	AGO3 →	+0.753	+0.076	<.001	<.001	3	31
UVM	LRIG2 →	+0.878	+0.067	<.001	<.001	3	31
DLBC	PARGP1 →	+0.799	+0.075	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030422 vs DICER1 — UVM

Explore this scatter interactively →