siRNA processing

Across TCGA patient cohorts, RNA activity of the siRNA processing pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4_S432, TLN1_S446, and FERMT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, siRNA processing activity versus SEPTIN4_S432 in HNSC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SEPTIN4_S432 →	+0.551	+0.101	.007	.006	3	5
OV	TLN1_S446 →	+0.498	+0.064	.008	.001	3	4
BRCA	FERMT2 →	+0.423	+0.047	<.001	<.001	3	4
OV	ITGAV →	+0.672	+0.077	<.001	<.001	3	4
OV	PTGIS →	+0.482	+0.047	.005	.003	3	4
CCRCC	ARRB2 →	+0.183	+0.047	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030422 vs SEPTIN4_S432 — HNSC

Explore this scatter interactively →