siRNA processing

Across TCGA patient cohorts, RNA activity of the siRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTC3-AS1, EIF4E3, and INPP4B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, siRNA processing activity versus TTC3-AS1 in BRCA (Pearson r = -0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TTC3-AS1 →	-0.327	-0.105	.001	.001	3	3
GBM	EIF4E3 →	-0.393	-0.782	.005	.002	3	3
UCEC	INPP4B →	+0.660	+0.206	.004	.001	3	3
COAD	HOXD-AS2 →	+0.617	+0.493	<.001	.006	3	2
COAD	RPS24P16 →	+0.231	+0.549	<.001	.001	3	2
PDAC	TEX12 →	+0.259	+0.104	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030422 vs TTC3-AS1 — BRCA

Explore this scatter interactively →