siRNA processing

Across TCGA patient cohorts, RNA activity of the siRNA processing pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CHGB_S149, LYST_S2128, and PRKRA_S130, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, siRNA processing activity versus CHGB_S149 in BRCA (Pearson r = 0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CHGB_S149 →	+2.242	+0.236	<.001	<.001	3	4
COAD	LYST_S2128 →	-0.501	-2.774	<.001	<.001	3	3
UCEC	PRKRA_S130 →	+0.558	+0.140	.004	.004	3	3
LSCC	CIC_T583 →	+0.663	+0.404	<.001	<.001	3	3
OV	AGO2 →	+0.350	+0.154	<.001	<.001	3	3
UCEC	NUP107_T64 →	+0.984	+0.208	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030422 vs CHGB_S149 — BRCA

Explore this scatter interactively →