siRNA processing

Across TCGA cell cohorts, RNA activity of the siRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKRA, SP3, and MAD2L1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, siRNA processing activity versus PRKRA in BLOOD_Leukemia (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRKRA →	+0.759	+0.595	<.001	.001	3	11
BLOOD_Leukemia	SP3 →	+0.678	+0.393	<.001	.001	3	6
UPPER_AERODIGESTIVE_TRACT	MAD2L1 →	+0.966	+1.048	.009	.005	3	6
LUNG_SCLC	CNOT9 →	+0.509	+0.694	.005	.006	3	6
LUNG_SCLC	EPC2 →	+0.634	+0.522	.001	.002	3	6
LUNG_SCLC	TSN →	+0.707	+0.754	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030422 vs PRKRA — BLOOD_Leukemia

Explore this scatter interactively →