Membrane disassembly

Across TCGA patient cohorts, RNA activity of the Membrane disassembly pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CTNND1, INPP4A, and PLEKHO1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane disassembly activity versus CTNND1 in HNSC (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CTNND1 →	-0.267	-0.073	<.001	<.001	3	7
HNSC	INPP4A →	+0.186	+0.067	.001	<.001	3	7
CCRCC	PLEKHO1 →	+0.323	+0.072	.001	<.001	3	7
COAD	TOR1A →	+0.268	+0.046	<.001	<.001	3	6
GBM	SEPTIN6_S388 →	+0.819	+0.060	<.001	<.001	3	6
CCRCC	CARMIL2_S1246 →	+0.570	+0.103	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030397 vs CTNND1 — HNSC

Explore this scatter interactively →