Membrane disassembly

Across TCGA patient cohorts, RNA activity of the Membrane disassembly pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDK2, TSPAN8, and SENP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane disassembly activity versus CDK2 in GBM (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CDK2 →	-0.456	-0.402	.004	.006	3	4
COAD	TSPAN8 →	+0.787	+0.544	.002	.005	3	4
PDAC	SENP1 →	-0.292	-0.143	.001	.003	3	4
LSCC	PRRG4 →	-0.480	-0.130	.008	<.001	3	4
GBM	TTPAL →	-0.318	-0.320	<.001	.009	3	3
GBM	E2F8 →	-0.556	-0.418	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030397 vs CDK2 — GBM

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