Membrane disassembly

Across TCGA cell cohorts, RNA activity of the Membrane disassembly pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNMT, BRMS1, and UCKL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNMT grouped by Membrane disassembly-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RNMT →	+0.542	+0.195	.008	.006	3	4
LIVER	BRMS1 →	+1.064	+0.263	.004	.001	3	4
KIDNEY	UCKL1 →	+0.715	+0.253	.006	.007	3	4
SKIN	HS1BP3 →	-0.588	-0.239	.008	.002	3	3
SKIN	PIM1 →	+0.989	+0.267	.001	.009	3	3
SKIN	SLC27A2 →	+0.520	+0.269	.009	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNMT by Membrane disassembly activity — LIVER

Explore this box plot interactively →