"Fructose 1,6-bisphosphate metabolic process"

Across TCGA patient cohorts, RNA activity of the "Fructose 1,6-bisphosphate metabolic process" pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALDOC, ERO1A, and DDX31, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Fructose 1,6-bisphosphate metabolic process" activity versus ALDOC in GBM (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ALDOC →	+0.452	+0.090	<.001	<.001	3	7
HNSC	ERO1A →	+0.572	+0.102	<.001	<.001	3	5
LUAD	DDX31 →	-0.230	-0.057	<.001	.004	3	5
GBM	PGAM1 →	+0.253	+0.098	.001	<.001	3	5
GBM	ATP6V1E1 →	+0.264	+0.075	<.001	<.001	3	5
GBM	XRN2 →	-0.171	-0.061	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030388 vs ALDOC — GBM

Explore this scatter interactively →