"Fructose 1,6-bisphosphate metabolic process"

Across TCGA patient cohorts, RNA activity of the "Fructose 1,6-bisphosphate metabolic process" pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCA, CAD, and PKMYT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Fructose 1,6-bisphosphate metabolic process" activity versus FANCA in UCEC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FANCA →	-0.616	-0.174	<.001	<.001	3	6
UCEC	CAD →	-0.558	-0.158	.002	.008	3	6
BRCA	PKMYT1 →	-1.102	-0.229	<.001	<.001	3	5
BRCA	CHTF18 →	-0.958	-0.206	<.001	<.001	3	5
BRCA	TEDC2 →	-0.779	-0.188	<.001	.001	3	5
UCEC	CHAF1A →	-0.579	-0.178	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030388 vs FANCA — UCEC

Explore this scatter interactively →