"Fructose 1,6-bisphosphate metabolic process"

Across TCGA cell cohorts, RNA activity of the "Fructose 1,6-bisphosphate metabolic process" pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PFKM, PFKP, and NUMBL, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Fructose 1,6-bisphosphate metabolic process" activity versus PFKM in URINARY_TRACT (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PFKM →	+1.527	+0.214	<.001	<.001	3	18
BREAST	PFKP →	+1.572	+0.094	.006	.005	2	12
LIVER	NUMBL →	+1.220	+0.187	<.001	.001	3	11
OESOPHAGUS	SYNGAP1 →	+1.157	+0.145	<.001	.003	3	11
BLOOD_Lymphoma	NAB2 →	+1.604	+0.162	<.001	<.001	3	11
LIVER	EHD3 →	+1.850	+0.235	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030388 vs PFKM — URINARY_TRACT

Explore this scatter interactively →