"Fructose 1,6-bisphosphate metabolic process"

Across TCGA cell cohorts, RNA activity of the "Fructose 1,6-bisphosphate metabolic process" pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF330, ALDOA, and PIP4K2A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Fructose 1,6-bisphosphate metabolic process" activity versus ZNF330 in STOMACH (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZNF330 →	+1.107	+0.401	.002	.004	3	7
LIVER	ALDOA →	+1.348	+0.311	.001	.005	3	5
BLOOD_Leukemia	PIP4K2A →	+1.211	+0.099	.004	.008	3	5
OVARY	CGN →	-2.905	-0.447	.003	.002	3	5
LIVER	MYO5C →	-1.754	-0.220	.002	.001	3	4
LIVER	NUCB2 →	+1.478	+0.325	.006	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030388 vs ZNF330 — STOMACH

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