"DNA damage response, signal transduction by p53 class mediator"

Across TCGA patient cohorts, RNA activity of the "DNA damage response, signal transduction by p53 class mediator" pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CRTAP, C1S, and RCN3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "DNA damage response, signal transduction by p53 class mediator" activity versus CRTAP in GBM (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CRTAP →	+0.594	+0.036	<.001	.001	3	7
CCRCC	C1S →	+0.544	+0.034	<.001	.001	3	7
GBM	RCN3 →	+0.980	+0.045	<.001	<.001	3	6
COAD	CTHRC1 →	+0.994	+0.028	<.001	.001	3	6
COAD	MMP14 →	+0.349	+0.025	<.001	<.001	3	6
GBM	P4HA2 →	+0.644	+0.033	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030330 vs CRTAP — GBM

Explore this scatter interactively →