"DNA damage response, signal transduction by p53 class mediator"

Across TCGA cell cohorts, RNA activity of the "DNA damage response, signal transduction by p53 class mediator" pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNRPD3, SLC25A29, and LRRC4B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNRPD3 grouped by "DNA damage response, signal transduction by p53 class mediator"-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SNRPD3 →	+0.813	+1.127	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	SLC25A29 →	+2.199	+0.326	.002	.004	3	4
SOFT_TISSUE	LRRC4B →	-1.869	-0.248	<.001	.003	3	3
SOFT_TISSUE	ARID4B →	-0.542	-0.261	.003	.001	3	3
CNS	RPS16 →	+0.475	+0.896	.004	.006	3	3
CNS	EDEM3 →	-0.504	-0.853	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNRPD3 by "DNA damage response, signal transduction by p53 class mediator" activity — LARGE_INTESTINE

Explore this box plot interactively →