"DNA damage response, signal transduction by p53 class mediator"

Across TCGA cell cohorts, RNA activity of the "DNA damage response, signal transduction by p53 class mediator" pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OPN1SW, EIF6, and MASP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OPN1SW grouped by "DNA damage response, signal transduction by p53 class mediator"-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OPN1SW →	-0.169	-0.060	.004	.002	3	6
PANCREAS	EIF6 →	-0.421	-0.046	.002	.001	3	4
PANCREAS	MASP2 →	-0.388	-0.045	.001	<.001	3	4
SKIN	CDKN1A →	-0.423	-0.098	<.001	<.001	3	4
KIDNEY	CHRNB3 →	+0.178	+0.084	.005	.006	3	4
SKIN	SH2D1B →	-0.275	-0.085	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OPN1SW by "DNA damage response, signal transduction by p53 class mediator" activity — CNS

Explore this box plot interactively →