"DNA damage response, signal transduction by p53 class mediator"

Across TCGA cell cohorts, RNA activity of the "DNA damage response, signal transduction by p53 class mediator" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PML, MVP, and IL7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "DNA damage response, signal transduction by p53 class mediator" activity versus PML in LUNG_NSCLC_LUAD (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PML →	+1.204	+1.292	<.001	<.001	3	8
STOMACH	MVP →	+2.145	+1.271	.002	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	IL7 →	+1.302	+1.226	.007	.002	3	7
OVARY	IFI44 →	+3.452	+1.364	.002	.001	3	6
STOMACH	ASPH →	+1.606	+1.442	.008	.006	2	7
LUNG_NSCLC_LUAD	MEIS3 →	-1.942	-1.060	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030330 vs PML — LUNG_NSCLC_LUAD

Explore this scatter interactively →