Adrenal gland development

Across TCGA patient cohorts, RNA activity of the Adrenal gland development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ASPN, THBS3, and TIMP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adrenal gland development activity versus ASPN in OV (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ASPN →	+0.905	+0.045	<.001	<.001	3	8
OV	THBS3 →	+0.582	+0.069	.002	<.001	3	8
BRCA	TIMP2 →	+0.593	+0.045	<.001	<.001	3	8
OV	TNS2_S102 →	+0.859	+0.053	<.001	.001	3	8
CCRCC	ACTN1 →	+0.444	+0.061	<.001	.003	3	8
OV	VCL_S795 →	+0.528	+0.047	.005	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030325 vs ASPN — OV

Explore this scatter interactively →