Adrenal gland development

Across TCGA patient cohorts, RNA activity of the Adrenal gland development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTK6, WDR35, and NF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adrenal gland development activity versus PTK6 in CCRCC (Pearson r = -0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PTK6 →	-0.420	-0.503	.001	<.001	3	4
CCRCC	WDR35 →	+0.221	+0.493	.008	<.001	3	4
BRCA	NF1 →	+0.475	+0.275	.002	.004	3	4
HNSC	COMP →	+0.954	+0.197	.001	.004	3	4
LUAD	FGF1 →	+0.627	+0.346	.001	.005	3	4
UCEC	ADGRD1 →	+0.676	+0.409	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030325 vs PTK6 — CCRCC

Explore this scatter interactively →