Adrenal gland development

Across TCGA cell cohorts, RNA activity of the Adrenal gland development pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLCD2, SOCS3, and SMPD1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adrenal gland development activity versus TLCD2 in CNS (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TLCD2 →	-0.566	-0.440	.003	.007	3	3
BLOOD_Leukemia	SOCS3 →	-2.667	-0.396	.003	.008	3	3
OVARY	SMPD1 →	+1.337	+0.387	.007	.008	3	2
OESOPHAGUS	METTL9 →	-0.634	-1.360	.001	.006	3	2
OESOPHAGUS	KMT2B →	-1.019	-1.483	.003	.006	2	3
OESOPHAGUS	RIOK2 →	-0.800	-1.796	.008	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030325 vs TLCD2 — CNS

Explore this scatter interactively →