Transepithelial chloride transport

Across TCGA patient cohorts, RNA activity of the Transepithelial chloride transport pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC12A2, KDELC1P1, and ANKRD53, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transepithelial chloride transport activity versus SLC12A2 in COAD (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SLC12A2 →	+0.923	+0.872	<.001	.001	3	7
LUAD	KDELC1P1 →	+0.577	+0.641	.001	.006	3	4
LSCC	ANKRD53 →	-0.337	-0.720	.001	.001	3	3
GBM	NFIL3 →	-0.637	-0.289	<.001	.001	3	3
GBM	SSXP10 →	+0.326	+0.268	<.001	<.001	3	3
UCEC	LINC01184 →	+0.485	+0.431	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030321 vs SLC12A2 — COAD

Explore this scatter interactively →