Transepithelial chloride transport

Across TCGA cell cohorts, RNA activity of the Transepithelial chloride transport pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLCNKB, ETFRF1, and EPDR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLCNKB grouped by Transepithelial chloride transport-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CLCNKB →	-0.354	-1.860	.006	.005	2	6
SOFT_TISSUE	ETFRF1 →	+0.271	+1.580	<.001	<.001	3	5
SOFT_TISSUE	EPDR1 →	-0.211	-1.288	.007	.006	3	5
LARGE_INTESTINE	OSTM1 →	-0.303	-1.528	.002	<.001	3	5
BLOOD_Myeloma	HTR6 →	-0.268	-1.485	.002	.002	3	5
BLOOD_Myeloma	SLC26A6 →	-0.140	-1.636	.005	<.001	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLCNKB by Transepithelial chloride transport activity — BLOOD_Myeloma

Explore this box plot interactively →