Transepithelial chloride transport

Across TCGA cell cohorts, RNA activity of the Transepithelial chloride transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMTC1, CBWD6, and NUF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMTC1 grouped by Transepithelial chloride transport-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TMTC1 →	+1.627	+1.426	.003	.003	3	4
KIDNEY	CBWD6 →	+1.297	+1.594	<.001	<.001	3	4
BLOOD_Lymphoma	NUF2 →	+1.682	+1.789	.003	<.001	3	4
BLOOD_Lymphoma	MTBP →	+1.620	+1.698	.003	<.001	3	4
OESOPHAGUS	SPATA25 →	+0.822	+1.123	<.001	.001	3	4
LARGE_INTESTINE	DUSP16 →	-1.077	-0.922	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMTC1 by Transepithelial chloride transport activity — BLOOD_Myeloma

Explore this box plot interactively →