Melanocyte differentiation

Across TCGA patient cohorts, RNA activity of the Melanocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DAB2, FILIP1L, and LUM, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Melanocyte differentiation activity versus DAB2 in GBM (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DAB2 →	+0.643	+0.069	<.001	<.001	3	9
UCEC	FILIP1L →	+1.014	+0.105	<.001	<.001	3	9
OV	LUM →	+1.008	+0.070	<.001	<.001	3	9
UCEC	PRKG1 →	+0.996	+0.107	<.001	<.001	3	9
GBM	GIMAP8 →	+0.507	+0.070	<.001	<.001	3	9
UCEC	SORBS3 →	+0.508	+0.088	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030318 vs DAB2 — GBM

Explore this scatter interactively →