Melanocyte differentiation

Across TCGA patient cohorts, RNA activity of the Melanocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OLFML1, IL1R1, and CYP1B1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Melanocyte differentiation activity versus OLFML1 in HNSC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OLFML1 →	+0.548	+0.307	.002	.003	3	5
GBM	IL1R1 →	+1.248	+0.322	<.001	<.001	3	4
LSCC	CYP1B1 →	+0.684	+0.422	<.001	.001	3	4
LSCC	AGTR1 →	+0.298	+0.601	.007	<.001	3	4
LSCC	CDCA5 →	-0.414	-0.428	.006	.001	3	4
GBM	LRMDA →	+0.674	+0.460	<.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030318 vs OLFML1 — HNSC

Explore this scatter interactively →