Melanocyte differentiation

Across TCGA patient cohorts, RNA activity of the Melanocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDK7, WDR4, and NPM1_S254, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Melanocyte differentiation activity versus CDK7 in OV (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CDK7 →	-0.297	-0.574	<.001	.001	3	4
UCEC	WDR4 →	-0.433	-0.256	<.001	<.001	3	3
BRCA	NPM1_S254 →	-1.143	-0.189	<.001	<.001	3	3
HNSC	RCSD1_S298 →	+0.584	+0.266	<.001	.001	3	3
LSCC	SHE_S69 →	+0.639	+0.625	<.001	<.001	3	3
UCEC	TNS2_S941 →	+0.416	+0.233	<.001	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030318 vs CDK7 — OV

Explore this scatter interactively →