Melanocyte differentiation

Across TCGA cell cohorts, RNA activity of the Melanocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTF2H5, COA8, and CDK9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GTF2H5 grouped by Melanocyte differentiation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GTF2H5 →	-0.662	-1.047	<.001	.001	3	4
LUNG_NSCLC_LUSC	COA8 →	-1.028	-1.449	.004	.003	3	4
BONE	CDK9 →	+0.772	+1.296	.002	.009	3	4
SKIN	NEDD8 →	-0.447	-0.918	<.001	<.001	3	4
STOMACH	EIF3M →	-0.561	-0.879	.009	.009	3	3
LUNG_NSCLC_LUAD	MYRF →	-1.990	-1.056	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GTF2H5 by Melanocyte differentiation activity — OESOPHAGUS

Explore this box plot interactively →