Melanocyte differentiation

Across TCGA cell cohorts, RNA activity of the Melanocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPHA1, GPC1, and SLC37A3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Melanocyte differentiation activity versus EPHA1 in SKIN (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	EPHA1 →	-0.506	-0.917	.004	.008	3	3
SKIN	GPC1 →	-1.690	-1.628	<.001	<.001	3	3
STOMACH	SLC37A3 →	+0.893	+1.841	.006	.001	3	3
SKIN	SEC14L2 →	-1.093	-1.285	.009	.001	3	2
SKIN	HPS4 →	+1.195	+1.468	<.001	<.001	3	2
SKIN	POFUT1 →	-0.605	-1.379	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030318 vs EPHA1 — SKIN

Explore this scatter interactively →