Osteoclast differentiation

Across TCGA patient cohorts, RNA activity of the Osteoclast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DENND3, CCRL2, and ALOX5AP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Osteoclast differentiation activity versus DENND3 in UCEC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DENND3 →	+0.497	+0.451	<.001	.003	3	6
GBM	CCRL2 →	+0.760	+0.523	<.001	<.001	3	6
GBM	ALOX5AP →	+1.384	+0.554	<.001	<.001	3	6
GBM	FAS →	+1.305	+0.665	<.001	<.001	3	6
GBM	CD4 →	+1.130	+0.696	<.001	<.001	3	5
GBM	MS4A6A →	+0.926	+0.500	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030316 vs DENND3 — UCEC

Explore this scatter interactively →