Osteoclast differentiation

Across TCGA cell cohorts, RNA activity of the Osteoclast differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFAP2, NUPR2, and SF3A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MFAP2 grouped by Osteoclast differentiation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MFAP2 →	-0.344	-0.228	.004	.007	3	4
BREAST	NUPR2 →	-0.264	-0.221	.006	.005	3	4
PANCREAS	SF3A1 →	+0.335	+0.270	.006	.001	3	4
LUNG_SCLC	PTP4A3 →	-0.144	-0.213	.009	.001	2	5
LIVER	RPL21P44 →	+0.413	+0.269	.008	.005	3	4
BLOOD_Leukemia	HLA-DPA1 →	-0.174	-0.164	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MFAP2 by Osteoclast differentiation activity — STOMACH

Explore this box plot interactively →