Osteoclast differentiation

Across TCGA cell cohorts, RNA activity of the Osteoclast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MESP1, ZNF710, and PRELID2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Osteoclast differentiation activity versus MESP1 in BLOOD_Lymphoma (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MESP1 →	+1.410	+0.348	<.001	<.001	3	5
LUNG_SCLC	ZNF710 →	-0.781	-0.265	.003	.001	3	5
BLOOD_Lymphoma	PRELID2 →	+1.896	+0.299	<.001	<.001	3	4
BLOOD_Lymphoma	ANXA2 →	+2.885	+0.309	<.001	<.001	3	4
BLOOD_Lymphoma	TLR9 →	-1.639	-0.310	<.001	<.001	3	4
BLOOD_Lymphoma	TTC9 →	-1.727	-0.251	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030316 vs MESP1 — BLOOD_Lymphoma

Explore this scatter interactively →